| Compounds | Topics | Title | Date |
|---|---|---|---|
| JWH-015,WIN55 | cancer,lung cancer in vitro | Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis | Nov 2010 |
|
Action Pathway: CB1,CB2 Furthermore, we have shown that the treatment of NSCLC cell lines (A549 and SW-1573) with CB1/CB2 and CB2-specific agonists Win55,212-2 and JWH-015, respectively, significantly attenuated random as well as growth factor-directed in vitro chemotaxis and chemoinvasion in these cells | |||
| Geraniol | cancer,breast cancer,lung cancer via review | The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review) | May 2016 |
| Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, prostate, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. | |||
| Guaiol | cancer,lung cancer in mice via experiment | (-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer | Sept 2016 |
|
Action Pathway: RAD51 The following mechanism studies show that (-)-Guaiol is involved in cell autophagy to regulate the expression of RAD51, leading to double-strand breaks triggered cell apoptosis. | |||
| cannabinoids | cancer,pancreatic cancer,lung cancer via review | Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids | Apr 2018 |
| This study explores the potential of combination approaches employing CBDs with radiotherapy (RT) or smart biomaterials toward enhancing therapeutic efficacy during treatment of pancreatic and lung cancers. | |||
| CBD | cancer,lung cancer in humans via case study (n=1) | Striking lung cancer response to self-administration of cannabidiol: A case report and literature review | Feb 2019 |
| Prior work has shown that cannabidiol may have anti-neoplastic properties and enhance the immune response to cancer. The data presented here indicate that cannabidiol might have led to a striking response in a patient with lung cancer. | |||
| THC | cancer,lung cancer in mice | Delta-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. | Jul 2000 |
| Negative In this study, we show that Delta-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, suppresses host immune reactivity against lung cancer. | |||
| CBD | cancer,lung cancer in mice | Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. | Apr 2012 |
| In athymic nude mice, CBD elicited a 2.6- and 3.0-fold increase of ICAM-1 and TIMP-1 protein in A549 xenografts, as compared to vehicle-treated animals, and an antimetastatic effect that was fully reversed by a neutralizing antibody against ICAM-1 [% metastatic lung nodules vs. isotype control (100%): 47.7% for CBD + isotype antibody and 106.6% for CBD + ICAM-1 antibody]. Overall, our data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequent decreased cancer cell invasiveness. | |||
| CBD | cancer,lung cancer in vitro | Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. | Nov 2014 |
| Cannabidiol (CBD), a non-psychoactive cannabinoid, enhanced the susceptibility of cancer cells to adhere to and subsequently be lysed by LAK cells, with both effects being reversed by a neutralizing ICAM-1 antibody | |||
| Nabilone | appetite boost,lung cancer in humans via placebo trial (n=65) | The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial. | Sep 2018 |
|
Ingestion Method: 0.5 mg/2 weeks followed by 1.0 mg/6 weeks Positive Nabilone increased their caloric intake (342-kcal) and had a significantly higher intake of carbohydrates (64 g) compared to patients receiving placebo (p = 0.040). Quality of life also showed significant improvements in patients in the experimental arm of the trial, particularly in role functioning (p = 0.030), emotional functioning (p = 0.018), social functioning (p = 0.036), pain (p = 0.06), and insomnia (p = 0.020). | |||
| Guaiol,Caryophyllene | cancer,lung cancer in vitro via experiment | Bulnesia sarmientoi Supercritical Fluid Extract Exhibits Necroptotic Effects and Anti-Metastatic Activity on Lung Cancer Cells. | Dec 2018 |
| alpha--Guaiene, (-)-guaiol and beta--caryophyllene are responsible for most of the cytotoxic activity of BSE against these two cancer cell lines. Since BSE possesses significant cytotoxicity and anti-metastatic activity on A549 and H661 cells, it may serve as a potential target for the treatment of lung cancer. | |||